It is a reducing sugar and undergoes mutarotation. The general formula for disaccharides is Cₙ(H₂O)ₙ₋₁. It results from joini ng two glucose units with an α(1→4) bonding. Some examples of these sugars are sucrose, lactose, glucose, maltose, etc. Lower molecular weight carbohydrates are generally known as sugars, and their name ends in the characteristic ‘ose’. They are composed of carbon, hydrogen, and oxygen. Together, these structures provide insight into how the hinge-bending movement of GGBP facilitates ligand binding, transport, and signaling.ĭepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.Carbohydrates are the essential components of food. Furthermore, the high-quality data collected for the atomic resolution glucose-bound structure allow for the refinement of specific hydrogen atom positions, the assignment of alternate side chain conformations, the first description of CO(2) trapped after radiation-induced decarboxylation, and insight into the role of the exo-anomeric effect in sugar binding. A comparison with the closely related periplasmic receptors, ribose- and allose-binding proteins, shows that the GGBP hinge residue positions that undergo the largest conformational changes are different. These structures vary in the angle between the two structural domains the observed difference of 31 degrees arises from torsion angle changes in a three-segment hinge.

We report a 0.92 angstroms resolution structure of GGBP from Escherichia coli in the glucose-bound state and the first structure of an open, unbound form of GGBP (at 1.55 angstroms resolution).

GGBP, like other periplasmic binding proteins, can exist in open (ligand-free) and closed (ligand-bound) states.

Diversity, Equity, Inclusion, and Accessĭ-Glucose/D-Galactose-binding protein (GGBP) mediates chemotaxis toward and active transport of glucose and galactose in a number of bacterial species.Citation, Usage, Privacy Policies, Logo.Biologically Interesting Molecule Reference Dictionary (BIRD).

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